SCA® Toxicology

Specialized system for toxicology centers working with mouse and rat

SCA® Motility and Concentration TOX

  • Module for the automatic analysis of sperm motility and concentration in a semen sample of mouse or rat.
  • Ideal for testing various drugs, chemicals and radiations for their toxicity. This system adheres to 21 CFR11 guidelines
  • Detects the spermatozoa automatically
  • Samples are analyzed under negative phase contrast (mouse) and pseudo phase contrast (rat)

SCA® Morphology TOX

  • Module for the automatic morphometry analysis and morphology classification of stained sperm samples of mouse and rat observed in brightfield microscopy
  • Ideal for testing various drugs, chemicals and radiations for their toxicity. This system adheres to 21 CFR11 guidelines
  • Detects and analyzes the spermatozoa automatically.
  • Simultaneously evaluates the dimensions of the head and midpiece as well as arc length and chord
  • Spermatozoa are recorded as normal or abnormal, following established criteria: Standard, Adaptative or Customized
  • SpermBlue® staining is the only available stain for correct visualization, which has been validated with the SCA®

SCA® DNA Fragmentation TOX

  • Module for the automatic counting of DNA fragmented and non fragmented spermatozoa, in samples of mouse and rat treated with kits based on the Sperm Chromatin Dispersion (SCD) as Halomax®
  • DNA fragmentation identifies a unique mark of apoptosis, and is usually associated with structural changes in cellular morphology
  • Spermatozoa are recognized and classified automatically into fragmented or non fragmented spermatozoa, following the established analysis criteria
 

SCA® Vitality TOX

  • Module that automatically provides the percentage of live and dead spermatozoa in a semen sample of mouse and rat
  • Sperm Vitality is estimated by assessing the membrane integrity of the cells, and is fundamental for samples having less than 40% progressive motile spermatozoa
  • Percentage of the viable cells normally exceeds that of motile cells
  • Analysis is performed under fluorescence microscopy, in samples stained with FluoVit vital staining, that allows the differentiation between alive sperm (in blue), and the dead sperm (in red).
  • Spermatozoa are recognized and classified automatically
 
 
  • SCA-PACK- TOX-01     SCA® Pack TOX Edition: 1. SCA® Motility and Concentration + 2. SCA® Morphology + 3. SCA® Manual Counter